synthesis and antimicrobial evaluation of n-substituted-5- benzylidene-2,4-thiazolidinedione derivatives
نویسندگان
چکیده
a series of n-substituted-2,4-thiazolidinedione derivatives (tzds) were prepared via n-alkylation of 2,4-tzd at position 3 using substituted benzyl halides. synthesized n-substituted-2,4-tzd was then substituted at position 5 with substituted aromatic aldehyde according to knoevenagel condensation method. structures of the compounds were elucidated using various spectral techniques viz. ir, 1hnmr. the synthesized compounds were evaluated for their antimicrobial activity.
منابع مشابه
Synthesis and Antimicrobial Evaluation of N-Substituted-5- Benzylidene-2,4-Thiazolidinedione Derivatives
A series of N-substituted-2,4-thiazolidinedione derivatives (TZDs) were prepared via N-alkylation of 2,4-TZD at position 3 using substituted benzyl halides. Synthesized N-substituted-2,4-TZD was then substituted at position 5 with substituted aromatic aldehyde according to Knoevenagel condensation method. Structures of the compounds were elucidated using various spectral techniques viz. I...
متن کاملSynthesis and Antimicrobial Evaluation of N-Substituted-5- Benzylidene-2,4-Thiazolidinedione Derivatives
A series of N-substituted-2,4-thiazolidinedione derivatives (TZDs) were prepared via N-alkylation of 2,4-TZD at position 3 using substituted benzyl halides. Synthesized N-substituted-2,4-TZD was then substituted at position 5 with substituted aromatic aldehyde according to Knoevenagel condensation method. Structures of the compounds were elucidated using various spectral techniques viz. IR, 1HN...
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عنوان ژورنال:
iranian journal of pharmaceutical sciencesجلد ۸، شماره ۳، صفحات ۲۰۹-۲۱۴
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